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Life as we know it descended from a single cell. What do we know about LUCA?

Who was the "last universal common ancestor" of all life on Earth? LUCA may have already had the core components of modern cells some 4.2 billion years ago.
Robert Neubecker/Quanta Magazine
Who was the "last universal common ancestor" of all life on Earth? LUCA may have already had the core components of modern cells some 4.2 billion years ago.

Imagine the tree of life. The tip of every branch represents one species, whether you're talking about humans, E. coli, tardigrades, baker's yeast or giant kelp.

If you follow any two branches back through time, you'll hit an intersection. That's the common ancestor of those two species. For example, the common ancestor of humans and chimps lived less than 10 million years ago.

But what if you keep going back in time?

Eventually you'll find the common ancestor for all vertebrates, then all animals and then all eukaryotes. And eventually, for all of life as we know it. That ancestor is called LUCA: the last universal common ancestor.

NPR science correspondent Jonathan Lambert joins Short Wave to talk about LUCA: What we think this single-celled organism may have looked like, when it lived and why a recent study suggests it could be older and more complex than scientists thought.

Click here to read Jon's original article in Quanta Magazine.

Have other questions about ancient biology? Email us at shortwave@npr.org — we'd love to hear from you!

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This episode was produced by Berly McCoy. It was edited by our showrunner, Rebecca Ramirez. The audio engineer was Gilly Moon. Tyler Jones checked the facts.

Copyright 2025 NPR

Emily Kwong (she/her) is the reporter for NPR's daily science podcast, Short Wave. The podcast explores new discoveries, everyday mysteries and the science behind the headlines — all in about 10 minutes, Monday through Friday.
Berly McCoy
Kimberly (Berly) McCoy (she/her) is an assistant producer for NPR's science podcast, Short Wave. The podcast tells stories about science and scientists, in all the forms they take.
Rebecca Ramirez (she/her) is the founding producer of NPR's daily science podcast, Short Wave. It's a meditation in how to be a Swiss Army Knife, in that it involves a little of everything — background research, finding and booking sources, interviewing guests, writing, cutting the tape, editing, scoring ... you get the idea.