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Toxicity is a good defense, until it isn't

Close-up of cane toad on pebbled surface, Australia.
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Close-up of cane toad on pebbled surface, Australia.

Imagine, you're a toxic toad hanging around South America. No other animals are gonna mess with you, right? After all, if anyone tries to eat you, they'll be exposed to something called a cardiotonic steroid — and may die of a heart attack.

Well, unfortunately for at least cane toads, some other animals have developed adaptations to their toxic steroids.

Evolutionary biologist Shabnam Mohammadi has spent her career studying how these adaptations work — and says humans have used these toxins to their advantage since ancient Egypt.

"To this day, we still do that actually," Mohammadi says. "Some versions of cardiotonic steroids are prescribed for treating congestive heart failure."

Today on the show, we explore the uses for these toxins and talk to Mohammadi about the adaptations that allow some predators to consume cardiotonic steroids without getting sick.

Curious about biology? Email us at shortwave@npr.org.

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This episode was produced by Rachel Carlson, edited by Rebecca Ramirez and fact-checked by Tyler Jones. Kwesi Lee was the audio engineer.

Copyright 2025 NPR

Regina G. Barber
Regina G. Barber is Short Wave's Scientist in Residence. She contributes original reporting on STEM and guest hosts the show.
Rachel Carlson
Rachel Carlson (she/her) is a production assistant at Short Wave, NPR's science podcast. She gets to do a bit of everything: researching, sourcing, writing, fact-checking and cutting episodes.
Rebecca Ramirez (she/her) is the founding producer of NPR's daily science podcast, Short Wave. It's a meditation in how to be a Swiss Army Knife, in that it involves a little of everything — background research, finding and booking sources, interviewing guests, writing, cutting the tape, editing, scoring ... you get the idea.
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