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Go on, pick a favorite in this year's NCAA tournament. We dare you. There's more than a dozen legitimate contenders to pick from. And then there's all those potential Cinderella teams. Mike Pesca talks to Audie Cornish about the upcoming NCAA Men's College Basketball tournament, which is as wide open as it has even been.

Witnesses say the blast happened in the late afternoon. The sound of shots followed. As night fell, at least two attackers were dead. A small number of civilians had been wounded. Offices of the International Organization for Migration appear to have been targeted.

Wells Fargo will pay a $1 billion fine to settle claims that it had taken advantage of mortgage and auto loan customers. Federal regulators also said the bank did not have adequate compliance or risk management programs.

Hurricane Harvey dumped 50 inches of rain on parts of Houston. Scientists are now trying to identify contaminants spread by the storm, including those in mud at the bottom of the Houston Ship Channel.

Republican lawmakers unveiled a new tax plan this week. While the rollout went well — much better than healthcare — there are a handful of issues at stake that the GOP will have to answer for.

"My wife is absolutely obsessed that she's ready for Christmas," Ed Fuller says. "Last Christmas, we sort of lost."

New talks on Capitol Hill about a government spending proposal signal the White House is backing down from its demand for $5 billion for a border wall as they try to fashion a deal before Friday's deadline

Incoming presidents increase the departure rate of senior level employees, a new study of 6 million federal workers finds. NPR's Ari Shapiro talks with one author of the study, John M. de Figueiredo, to learn more about how this will impact the Trump administration.

The administration is pledging $100 million toward a project to stop HIV infections once and for all. There's growing optimism among scientists that it may be possible to get patients' immune systems to control HIV without drugs, or even to eliminate the virus from the cells of infected people someday.

On Tuesday, the Democratic nominee shared the debate stage with President Trump, who has tested positive for the virus.