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"Given the findings and the commissioner's ruling, we collectively decided that it would not be possible for Alex to effectively lead the club going forward," the team said in a statement.
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The changes follow the death of Los Angeles Angels pitcher Tyler Skaggs, who was found with opioids and alcohol in his system.
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A federal grand jury has indicted former Yankees pitcher Roger Clemens, charging him with one count of obstruction of Congress, three counts of making false statements and two counts of perjury.